Correlation of Base-Line Trough Tacrolimus Level With Early Rejection
نویسندگان
چکیده
منابع مشابه
Higher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection.
We analyzed the association between whole-blood trough tacrolimus (TAC) levels in the first days post-kidney transplant and acute cellular rejection (ACR) rates. Four hundred and sixty-four consecutive, deceased-donor kidney transplant recipients were included. All were treated with a combination of TAC, mycophenolate mofetil and prednisolone. Patients were analyzed in four groups based on quar...
متن کاملGlucose metabolism in renal transplant recipients on tacrolimus: the effect of steroid withdrawal and tacrolimus trough level reduction.
The relative role of steroids and tacrolimus in the development of glucose metabolic disorders and hyperlipidemia after renal transplantation has not yet been clearly established. Therefore, glucose metabolism was prospectively evaluated by intravenous glucose tolerance test, as was lipid profile, in fifteen white nondiabetic renal transplant recipients three times: before and after steroid wit...
متن کاملEvidence of different pharmacokinetics including relationship among AUC, peak, and trough levels between cyclosporine and tacrolimus in renal transplant recipients using new pharmacokinetic parameter--why cyclosporine is monitored by C(2) level and tacrolimus by trough level--.
The clinical efficacy of calcineurin inhibitors administered to renal transplant patients is considered to be a strong function of the area under the concentration time curve (AUC). Interestingly, monitoring timings of blood concentrations for two similar calcineurin inhibitors, cyclosporine (CYA; Neoral) and tacrolimus (TAC; Prograf) are different. Namely, CYA blood concentration is usually mo...
متن کاملFive-year experience with tacrolimus rescue for renal allograft rejection.
TACROLIMUS is safe and effective for primary renal . transplantation,l but perhaps even more striking is the utility of this drug as a salvage agent for refractory renal allograft rejection.2 We previously reported that graft salvage with tacrolimus conversion was achieved in 74% (57 of 77) of patients with refractory acute rejection on baseline cyclosporine (CyA) therapy.2 Since then, we have ...
متن کاملLow tacrolimus concentrations and increased risk of early acute rejection in adult renal transplantation.
BACKGROUND A retrospective analysis was performed on adult renal transplant recipients to evaluate the relationship between tacrolimus trough concentrations and the development of rejection in the first month after transplant. METHODS A total of 349 concentrations from 29 patients, measured by enzyme-linked immunosorbent assay (ELISA), were recorded. Based on an increased serum creatinine, 12...
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ژورنال
عنوان ژورنال: Surgical Medicine Open Access Journal
سال: 2018
ISSN: 2578-0379
DOI: 10.31031/smoaj.2018.01.000510